ROS-Inducible DNA Cross-Linking Agent as a New Anticancer Prodrug Building Block

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.

Two new small compounds, which undergo fluoride-mediated self rearrangement, produce active DNA alkylating agent nitrogen mustard leading to DNA damage and finally cell death, providing potential antitumor prodrugs.

متن کامل

Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1

Hypoxia activates hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis and by augmenting the ability of tumors to survive. Thus, HIF-1 is one of the most compelling targets for treating cancers. The aim of this study was to find a small molecule that inhibits HIF-1 under hypoxia in cancer cells. 7,280 compounds in a chemical library were tested in...

متن کامل

Runaway ROS as a selective anticancer strategy.

The majority of cancer therapies target macromolecules important for general cell survival, such as DNA, topoisomerase, and tubulin (e.g. , cisplatin, doxorubicin, and paclitaxel, respectively). While these agents are effective at killing many types of cancer cells, they also affect rapidly dividing normal cells, such as the intestinal lining and bone marrow, resulting in dose limiting toxiciti...

متن کامل

Reactive Oxygen Species (ROS) Inducible DNA Cross-Linking Agents and Their Effect on Cancer Cells and Normal Lymphocytes

Reducing host toxicity is one of the main challenges of cancer chemotherapy. Many tumor cells contain high levels of ROS that make them distinctively different from normal cells. We report a series of ROS-activated aromatic nitrogen mustards that selectively kill chronic lymphocytic leukemia (CLL) over normal lymphocytes. These agents showed powerful DNA cross-linking abilities when coupled wit...

متن کامل

Laccase-Based CLEAs: Chitosan as a Novel Cross-Linking Agent

Laccase from Coriolopsis Polyzona was insolubilized as cross-linked enzyme aggregates (CLEAs) for the first time with chitosan as the cross-linking agent. Concentrations between 0.01 and 1.867 g/L of chitosan were used and between 0.05 and 600 mM of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride. The laccase was precipitated using ammonium sulphate and cross-linked simultaneously. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemistry - A European Journal

سال: 2012

ISSN: 0947-6539

DOI: 10.1002/chem.201200075